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Thus, the concept is emerging that these tissues have, to a great degree, the same set of biosynthetic enzymes, but differ in the relative activities or amounts of different individual enzymes. ![]() Present developments of enzyme chemistry point toward a qualitative similarity of the biosynthetic systems in all tissues forming steroid hormones ( Samuels 1958). The embryological origin of these tissues from adjacent portions of the dorsal mesentery provided a plausible background for similarities ( Poll 1900, Politzer 1937, Gruenwald 1942). The production of sex hormones by congenital hyperplasias or malignancies of the adrenal cortex has long been recognized as suggestive of a biochemical relationship between the adrenal cortex and the gonads. Eventually, Bethesda scrapped the idea for The Elder Scrolls IV: Oblivion altogether, but in Fallout 3 they went the other way, allowing children for authenticity, but making them invincible. 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The +P ammunition does give increased velocities, even from 2-inch barrels, but the longer barrel lengths do make more efficient use of it. Is the extra powder being burned "after" the bullet is long gone? I'd also like to know from you guys what you think about +P out of a two inch barrel. Soooooo, I guess I'm not sure if the +P applies to my 30 year old Undercover or not.? When you load for protection, use a jacketed or hollow point in the same grain you practice with." We recommend a standard velocity load and practice with round nose lead rounds which are the least expensive. Therefore, in a two-inch barrel the extra powder is burned after the bullet leaves the barrel creating more recoil and making it harder to come back to target. +P ammo requires a four-inch minimum barrel to burn the extra powder. Yes they can handle +P but we do not recommend it for the following reasons: 38's are among the smallest revolvers in this caliber. 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